After months of waiting, the first full Sunday of NFL football did not disappoint.
And with that, Week 2 kicks off Thursday night, as the Green Bay Packers host the Washington Commanders.
Here are the lines for every Week 2 matchup at DraftKings Sportsbook as of Sept. 11.
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(All times ET)
2025 NFL Week 1 Odds
THURSDAY, SEPT. 11
COMMANDERS @ PACKERS (8:15 p.m., Prime Video)
Point spread: Packers -3.5 (Packers favored to win by 3.5 points or more, otherwise Commanders cover)
Moneyline: Packers -185 favorites to win (bet $10 to win $15.41 total); Commanders +154 underdogs to win (bet $10 to win $25.40 total)
Total Over/Under: 48.5 points scored by both teams combined
SUNDAY, SEPT. 14
JAGUARS @ BENGALS (1 p.m., CBS)
Point spread: Bengals -3.5 (Bengals favored to win by 3.5 points or more, otherwise Jaguars cover)
Moneyline: Bengals -170 favorites to win (bet $10 to win $15.88 total); Jaguars +142 underdogs to win (bet $10 to win $24.20 total)
Total Over/Under: 48.5 points scored by both teams combined
GIANTS @ COWBOYS (1 p.m., FOX)
Point spread: Cowboys -4.5 (Cowboys favored to win by 4.5 points or more, otherwise Giants cover)
Moneyline: Cowboys -225 favorites to win (bet $10 to win $14.44 total); Giants +185 underdogs to win (bet $10 to win $28.50 total)
Total Over/Under: 44.5 points scored by both teams combined
BEARS @ LIONS (1 p.m., FOX)
Point spread: Lions -6 (Lions favored to win by 6 points or more, otherwise Bears cover)
Moneyline: Lions -285 favorites to win (bet $10 to win $13.51 total); Bears +230 underdogs to win (bet $10 to win $33 total)
Total Over/Under: 46.5 points scored by both teams combined
RAMS @ TITANS (1 p.m., CBS)
Point spread: Rams -5.5 (Rams favored to win by 5.5 points or more, otherwise Titans cover)
Moneyline: Rams -230 favorites to win (bet $10 to win $14.35 total); Titans +190 underdogs to win (bet $10 to win $29 total)
Total Over/Under: 41.5 points scored by both teams combined
PATRIOTS @ DOLPHINS (1 p.m., CBS)
Point spread: Dolphins -1.5 (Dolphins favored to win by 1.5 points or more, otherwise Patriots cover)
Moneyline: Dolphins -118 favorites to win (bet $10 to win $18.47 total); Patriots -102 underdogs to win (bet $10 to win $19.80 total)
Total Over/Under: 43.5 points scored by both teams combined
49ERS @ SAINTS (1 p.m., FOX)
Point spread: 49ers -3 (49ers favored to win by 3 points or more, otherwise Saints cover)
Moneyline: 49ers -170 favorites to win (bet $10 to win $15.88 total); Saints +142 underdogs to win (bet $10 to win $24.20 total)
Total Over/Under: 40.5 points scored by both teams combined
BILLS @ JETS (1 p.m., CBS)
Point spread: Bills -6.5 (Bills favored to win by 6.5 points or more, otherwise Jets cover)
Moneyline: Bills -310 favorites to win (bet $10 to win $13.23 total); Jets +250 underdogs to win (bet $10 to win $35 total)
Total Over/Under: 46.5 points scored by both teams combined
SEAHAWKS @ STEELERS (1 p.m., FOX)
Point spread: Steelers -3 (Steelers favored to win by 3 points or more, otherwise Seahawks cover)
Moneyline: Steelers -166 favorites to win (bet $10 to win $16.02 total); Seahawks +140 underdogs to win (bet $10 to win $24 total)
Total Over/Under: 39.5 points scored by both teams combined
BROWNS @ RAVENS (1 p.m., CBS)
Point spread: Ravens -11.5 (Ravens favored to win by 11.5 points or more, otherwise Browns cover)
Moneyline: Ravens -800 favorites to win (bet $10 to win $11.25 total); Browns +550 underdogs to win (bet $10 to win $65 total)
Total Over/Under: 44.5 points scored by both teams combined
BRONCOS @ COLTS (4:05 p.m., CBS)
Point spread: Broncos -1.5 (Broncos favored to win by 1.5 points or more, otherwise Colts cover)
Moneyline: Broncos -130 favorites to win (bet $10 to win $17.69 total); Colts +110 underdogs to win (bet $10 to win $21 total)
Total Over/Under: 42.5 points scored by both teams combined
PANTHERS @ CARDINALS (4:05 p.m., CBS)
Point spread: Cardinals -6.5 (Cardinals favored to win by 6.5 points or more, otherwise Panthers cover)
Moneyline: Cardinals -298 favorites to win (bet $10 to win $13.36 total); Panthers +240 underdogs to win (bet $10 to win $34 total)
Total Over/Under: 43.5 points scored by both teams combined
EAGLES @ CHIEFS (4:25 p.m., FOX)
Point spread: Eagles -1.5 (Eagles favored to win by 1.5 points or more, otherwise Chiefs cover)
Moneyline: Eagles -125 favorites to win (bet $10 to win $18 total); Chiefs +105 underdogs to win (bet $10 to win $20.50 total)
Total Over/Under: 46.5 points scored by both teams combined
FALCONS @ VIKINGS (8:20 p.m., NBC)
Point spread: Vikings -3.5 (Vikings favored to win by 3.5 points or more, otherwise Falcons cover)
Moneyline: Vikings -185 favorites to win (bet $10 to win $15.41 total); Falcons +154 underdogs to win (bet $10 to win $25.40 total)
Total Over/Under: 44.5 points scored by both teams combined
MONDAY, SEPT 15
BUCCANEERS @ TEXANS (7 p.m., ABC/ESPN)
Point spread: Texans -2.5 (Texans favored to win by 2.5 points or more, otherwise Buccaneers cover)
Moneyline: Texans -135 favorites to win (bet $10 to win $17.41 total); Buccaneers +114 underdogs to win (bet $10 to win $21.40 total)
Total Over/Under: 42.5 points scored by both teams combined
CHARGERS @ RAIDERS (10 p.m., ESPN)
Point spread: Chargers -3 (Chargers favored to win by 3 points or more, otherwise Raiders cover)
Moneyline: Chargers -180 favorites to win (bet $10 to win $15.56 total); Raiders +150 underdogs to win (bet $10 to win $25 total)
Total Over/Under: 46.5 points scored by both teams combined
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